UNC93B1 mediates differential trafficking of endosomal TLRs
نویسندگان
چکیده
منابع مشابه
UNC93B1 mediates differential trafficking of endosomal TLRs
UNC93B1, a multipass transmembrane protein required for TLR3, TLR7, TLR9, TLR11, TLR12, and TLR13 function, controls trafficking of TLRs from the endoplasmic reticulum (ER) to endolysosomes. The mechanisms by which UNC93B1 mediates these regulatory effects remain unclear. Here, we demonstrate that UNC93B1 enters the secretory pathway and directly controls the packaging of TLRs into COPII vesicl...
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ژورنال
عنوان ژورنال: eLife
سال: 2013
ISSN: 2050-084X
DOI: 10.7554/elife.00291